While Novocaine is generally very safe, many patients report feeling unwell after the procedure. So, can Novocaine actually make you sick? The short answer is

Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult your dentist or physician about your specific health history and reactions to medications.

Here is a breakdown of why Novocaine can make you feel sick, what symptoms to expect, and when you should call a doctor. Most dental anesthetics contain epinephrine (adrenaline). Epinephrine is a vasoconstrictor—it keeps the anesthetic localized to the tooth area longer and reduces bleeding. However, adrenaline triggers your body’s "fight or flight" response.